FAQ Oxafence

Oxafence Active Protection™ Mask Spray

Instructions for Use
Shake gently. Apply 12 sprays evenly to mask’s outer surface from ~20cm. Allow to dry. Repeat daily or as often as desired. 

Please note, Oxafence Mask Spray is not available for sale or supply outside New Zealand.

Can I use Oxafence Mask Spray on Lanaco masks?

Oxafence Active Protection Mask Spray is recommended for use on face masks. This product, however, does not change the “intended use” of the product on which it is applied. Lanaco recommends Oxafence Mask Spray for added active protection on Waire™ P2 and Brezy™ Masks. Not currently recommended for use on other respirators, including P2/N95s/KN95s, unless specified by manufacturer.

Why do I need Oxafence Active Protection?

Masks trap or shield pathogens. Infectious levels of SARS-CoV-2 can remain present on the outer layer of masks for seven days. Oxafence Mask Spray adds an active layer of protection that kills SARS-CoV-2 and Flu viruses on your mask all day while you are wearing it. It’s additional protection for those who need or want it most. 

What are the Oxafence Mask Spray storage/usage instructions and additional considerations? 

Store Oxafence Active Protection Mask Spray in a cool, dry, dark location when not in use. Product may cause discoloration to fabrics or surfaces. Apply Oxafence Mask Spray with care to surrounding areas. Not intended to be swallowed or applied directly to skin. Do not use if hypersensitive to Methylene Blue. If pregnant, nursing, or taking medications with known interaction with ingredients, consult your physician prior to use. If an adverse reaction occurs, discontinue use and contact your physician while also notifying devices@health.govt.nz and info@oxafencenz.com

What ingredients are in Oxafence Mask Spray?

Oxafence Mask Spray includes simple ingredients: water and special-grade Methylene Blue (a protective dye).

Methylene Blue has been used as a textile dye since the 1870s and is considered an essential medicine by the World Health Organization. Methylene Blue has been commonly used for over one hundred years in treatment of disease, whether to mark skin or organs for surgeries, treat skin wounds, or as an injected or swallowed medication to treat poisonings or diseases such as malaria and methemoglobinemia.

The amount of Methylene Blue used in Oxafence Mask Spray is far lower than the amount already medically approved for intravenous or oral uses. 

How does Oxafence Mask Spray inactivate SARS-CoV-2 and FLU on masks?

Oxafence Mask Spray adds an active protective coating on masks. Methylene Blue, the protective dye in Oxafence Mask Spray, uses the power of visible light to enable the ongoing generation of singlet oxygen. Singlet oxygen is around us all the time, exists in our cells, and is naturally present in many commonly consumed products. Singlet oxygen is also well-known for its antimicrobial powers and ability to inactivate bacteria and viruses. Singlet oxygen kills SARS-CoV-2 and Influenza by disrupting their genomes, proteins, and outer shells.

The singlet oxygen generated by Oxafence Mask Spray rapidly and naturally changes back to the very oxygen that we breathe every day. This mode of pathogen inactivation is often called Photodynamic Inactivation (PDI). A similar method, Photodynamic Therapy (PDT), has been deployed clinically since the 1980s for treatment of skin, eye diseases and cancer. 

What research and data supports the Oxafence Active Protection technology? 

The “Development of Methods for Mask and N95 Decontamination” (DeMaND) Study demonstrated the efficacy of protective dyes (i.e., Methylene Blue) in decontaminating SARS-CoV-2 and other viruses from masks. This study, and many other follow-on studies, were conducted by a multinational COVID-19 Task Force of 52 researchers and 13 institutions. The WHO DeMaND Study also demonstrated that PPE pre-treated with Methylene Blue provided ongoing inactivation of coronaviruses.

Singletto, Inc. (the manufacturer of Oxafence Mask Spray) has continued to develop data supporting and expanding upon the DeMaND findings under the leadership of Dr Thomas Lendvay (pediatric surgeon), Dr James Chen (neurosurgeon), and Dr Christopher Mores (virologist). Singletto’s SARS-CoV-2 inactivation studies are performed by U.S.- and Canadian-based Biosafety Level 3 (BSL-3) University-affiliated laboratories. Oxafence Mask Spray is laboratory-verified to inactivate 99.9% of SARS-CoV-2 in thirty minutes in the ambient light commonly present in laboratories and normal indoor settings (~500-700 lux). Influenza A H1N1 inactivation studies are performed by an independent U.S. ISO-accredited laboratory. Oxafence Mask Spray is laboratory-verified to inactivate 95% of Influenza A H1N1 in thirty minutes in ambient light (~500 lux), and 99.99% in two hours.

One application (~12 sprays) of Oxafence Active Protection Mask Spray is also laboratory-verified to provide 24-hour protection from both SARS-CoV-2 and Influenza A H1N1 in ambient light (~500 lux). 

Is Oxafence Mask Spray effective as long as visible light is present?

The Photodynamic Inactivation (PDI) method is immediately active whenever visible light is present. Certain protective dyes (like Methylene Blue) provide quicker and stronger inactivation, however, when formulated for available lighting conditions.

Oxafence Mask Spray begins working in visible light but is specifically optimised for normal, indoor lighting environments where mask use/wear is common (typically ~500-700 lux).

Is Oxafence Mask Spray registered for sale in New Zealand? 

Oxafence Active Protection Mask Spray is WAND-listed and registered for sale in New Zealand as a Class IIb photocatalytic disinfectant surface coating [65345] intended to be applied to noninvasive soft surface devices to create a protective coating with an antimicrobial effect, that inactivates and decomposes harmful microorganisms through photodynamic action. This product, however, does not change the “intended use” of the product on which it is applied. Do not reuse a mask intended for single-use. Lanaco recommends Oxafence Mask Spray for added active protection on Waire™ P2 and Brezy™ Masks. Not currently recommended for use on other respirators, including P2/N95s/KN95s, unless specified by manufacturer.

Oxafence Mask Spray is not available for sale or supply outside New Zealand.